DNA Replication in Prokaryotes: Complete Mechanism, Enzymes, Steps & Animated Diagram

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DNA Replication in Prokaryotes: Complete Mechanism, Enzymes, Steps & Animated Diagram

Read Agriculture 8/21/2026 06:01:00 PM
Prokaryotic DNA Replication: Active Molecular Machinery Enzymatic Sequence & Asymmetric Bidirectional 5' → 3' Phosphodiester Polymerization 3' 5' 5' 3' SSB Multimers (Prevents secondary hairpins) LEADING STRAND: Continuous Synthesis (5' → 3' TOWARDS Fork) 5' RNA Primer DNA Pol III Holoenzyme 3'-OH + dNTPs LAGGING STRAND: Discontinuous Okazaki Fragments (5' → 3' AWAY from Fork) 5' 3'-OH (Nick site) Primase (DnaG) DNA Pol III Elongation + dNTP DNA Pol I 5'→3' Exonuclease Ligase (NAD+ / ATP) DnaB Helicase Unwinding Fork (ATP-driven) DNA Gyrase Relieves Supercoiling 1. Unwinding & Priming • DnaB separates template strands • Primase creates RNA primer 2. 5' → 3' Elongation • Pol III binds 3'-OH of primer • Incorporates complementary dNTPs 3. Primer Replacement • Pol I 5'→3' exonuclease degrades RNA • Fills gap with deoxyribonucleotides 4. Nick Ligation

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  1. AnonymousAugust 21, 2026 at 6:46 PM

    Very informative content bhai 😀

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